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the various methods differ in sensitivity, specificity (in particular, in distinguishing GSH from GSSG and other thiols), and susceptibility to matrix interference [119]

Treatment of large CT26 colon cancer tumors (1000 mm 3 ), with a volume known to be refractory to immune checkpoint therapy (ICT), with vitamin C in combination with the ICTs anti-CTLA-4 and anti-PD-1 led to tumor regression

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This activation contributes to enhanced resistance to oxidative stress, reduced inflammation, and a potentially decreased risk of chronic diseases 27,28

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Which brings us to the next question