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Similarly, vitamin D supplementation, although safe at recommended doses, can lead to hypercalcemia and hypercalciuria if administered in excess [151]

Arch.Toxicology

In an autocrine mechanism, SASP factors reinforce the cellular senescence of the senescent cells themselves, while in a paracrine mechanism, they are responsible for inducing senescence in surrounding cells [35]

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Stenson PD, Ball EV, Mort M, Phillips AD, Shiel JA, Thomas NS, Abeysinghe S, Krawczak M, Cooper DN

Research at Turku Bioscience Centre (LLE and RL) was supported by the University of Turku Graduate School (UTUGS), Biocenter Finland, ELIXIR Finland and by the InFLAMES Flagship Programme of the Academy of Finland (decision number: 337530)
