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Disclosure of interest: FAM, KG, VR, MK, WNW, KB, PH have nothing to disclose Poster Session II - RISK FACTORS - PRIMARY AND SECONDAR PREVENTION 05.00 - RISK FACTORS AND PREVENTION (PRIMARY AND SECONDARY) - 05.03 - EPIDEMIOLOGY & RISK FACTORS P1005 - ESOC25-1187 PREVALENCE AND OUTCOME OF CEREBRAL MICROBLEEDS IN ANTIPHOSPHOLIPID SYNDROME Jonathan Naftali 1 , Rani Barnea 1 , Ruth Eliahou 1 , Tzippy Shochat 1 , Adi Wilf-Yarkoni 1 , Sivan Bloch 2 , Michael Findler 1 , Avi Leader 3 , Walid Saliba 2 , Eitan Auriel 1 1 Rabin medical center, Tel Aviv University, Petah Tikva, Israel, 2 Carmel medical center, Haifa, Israel, 3 Memorial Sloan Kettering Cancer Center, New-York, United States Background and Aims: Antiphospholipid syndrome (APS) is an acquired autoimmune disease characterized by arterial and venous thrombosis

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A 2021 systematic review of 16 randomized controlled trials and 6,276 participants (Markun and colleagues, Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue, Nutrients, 2021) found that B12 supplementation does not reliably reduce fatigue in people who are not deficient

Firstly, it is not routinely tested, and secondly, low levels are often labeled as normal e.g