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[PubMed] [Google Scholar] 30.Strauss RR, Paul BB, Jacobs AA, and Sbarra AJ 1969

mTORC1 hinders ferroptosis by facilitating the uptake of cystine through xCT and subsequent synthesis of GSH, while it also directly enhances the synthesis of GPX4 to counteract ferroptosis (Xuan et al., 2022)

Widespread decrease of cerebral vimentin-Immunoreactive astrocytes in depressed suicides

Moreover, MDA promotes the aberrant aggregation of -syn by modifying its 15 lysine sites, thereby initiating Lewy body formation and driving the pathological process of PD (90)

[PubMed Citation] Bonfiglio MF, Traeger SM, Hulisz DT, Martin BR

GSH, also known as glutathione, possesses the ability to undergo oxidation, thereby contributing to the maintenance of redox homeostasis