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Despite the fact that this group of patients did not fit into any of the previously defined mitochondrial sickness categories, they showed autistic symptoms and 50% had large-scale mtDNA deletions [56]

Ferrostatin-1 prevents A-like aggregates, reduces lipid peroxidation and boosts the expression of iron storage in AD-cBOs Interestingly, A-like aggregates were observed in 50-days-old AD brain organoids compared to isogenic brain organoids (Fig

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Abbreviation: NA, not applicable