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The unbalanced p53/SIRT1 axis may impact lymphocyte homeostasis in COVID-19 patients
Similarly, Icariin has shown promising antidepressant effects (Zeng et al., 2022)

In Orai1 knockout mice, the LPS-induced depression-like behavior, including the helplessness and pleasure deficit, is improved in astrocytes (Novakovic et al., 2023)

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Active liver disease: The liver is the primary organ for copper metabolism

Effects were comparable to prednisolone, without the weight gain, metabolic disruption, or bone density loss associated with corticosteroids (PMC2095288)
