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The progression of T2D starts with insulin resistance followed by prediabetes, overt T2D with fasting blood glucose level above 126 mg/dL, and finally vascular damage [7,27]
Fabry disease is a multisystemic disease with life-threatening complications such as stroke, heart failure, cardiac arrhythmia, and end-stage renal disease (ESRD) that results in a reduction in life expectancy 3,4,5
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Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo
