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Under chronic or severe ER stress, PERK-mediated phosphorylation of eIF2 induces expression of ATF4 and a proapoptotic factor CHOP/GADD153, resulting in ER stress-induced apoptosis

It supports detoxification, immune function, and cellular repair

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Thus, the epigenetic dysregulation associated with endometriosis may preferentially be located in the ectopic endometrium, which shows a large amount of methylation differences compared either with the eutopic endometrium from healthy women or from the same patient