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These tumor cells, when they metastasize, carry bacteria to distant organs, promoting cytoskeletal reorganization and resistance to shear stress in the bloodstream, aiding metastasis survival (146)
Significantly, although methionine is identified as an important factor of nutritional epigenomics for maintaining T cell function, the tumor-derived or exogenous SAM metabolite also reprograms chromatin accessibilities of CD8 + T cells, leading to T cell dysfunction (50)

Despite these conceptual advances, current microbiome profiling methodsoften based on 16S rRNA sequencingprovide limited functional resolution, and only a subset of studies incorporates shotgun metagenomics or metabolomics to directly link microbial shifts to host pathways, leaving important mechanistic questions unresolved (7, 8)

Genetic predispositions affecting microbiota diversity or bile acid transformation can disrupt this balance, promoting inflammation and impaired bile acid recycling

10.3389/fnagi.2022.1029842 30

Based on the latest evidence-based findings, it is recommended to incorporate the following into guidelines: recommended intake of dietary fiber and prebiotics (2530 g/day)
