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Follow-up Repeat broad labs after 8-12 weeks if systemic use continues or symptoms change

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After a therapeutic dose, APAP is mostly converted to pharmacologically inactive glucuronide (APAP-gluc, 5257% of urinary metabolites) and sulfate (APAP sulfate, 3044%) conjugates, with a minor fraction being oxidized to a reactive metabolite NAPQI (510%) (Figure 1)
