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The liver has two pathways for detoxification

This powder form remains stable during shipping and storage but requires reconstitution with bacteriostatic water before use

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While the analysis of the entire PD cohort (including de novo patients and treated patients) in addition to the de novo patient-specific analysis allowed us to maximize statistical power to detect PD-associated changes, we also performed a dedicated analysis for treated patients only, using the same filtering and adjustment steps as for the entire PD dataset, to better distinguish changes in treated from treatment-nave patients

Cell line The human hepatocellular carcinoma cell line HepG2 (HB-8065) was obtained from the American Type Culture Collection (ATCC, Virginia, USA)

Ethics declarations Ethics approval This study was performed in line with the principles of the Declaration of Helsinki