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Lipoxygenase/Leukotriene Pathway Activation of 5-lipoxygenase (LOX) in ( primarily expressed in leukocytes ) results in the conversion of arachidonic acid to leukotrienes that function as inflammatory mediators (Wikipedia) resulting in: bronchoconstriction increased secretion of mucus leukocyte chemotaxis histamine release This pathway has its greatest clinical relevance in the pathophysiology of asthma

doi: 10.1093/jn/128.4.707

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Topical ketamine administration can treat neuropathic pain like Complex regional pain syndrome (CRPS), postherpetic neuralgia, and intractable neuropathic pain due to ulnar nerve entrapment [18,19,20,21,22]

Dosage Used: The amount of product used plays a big role in pricing, like treating a small under-eye area requires less product and costs less

DNA damage from chemotherapy can contribute to drug resistance in cancer cells (Goldstein and Kastan, 2015), cause collateral damage to healthy tissues (Liu et al., 2021), and increase the risk of secondary malignancies due to mutagenic effects (Marcus et al., 2021)