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The Bioavailability Problem with Oral Glutathione Most glutathione supplements fail because GSH is broken down into its constituent amino acids by gamma-glutamyltransferase (GGT) and dipeptidases in the intestinal lumen before it can enter circulation

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Additionally, senescent cells produce matrix metalloproteinases (MMPs) and other proteolytic enzymes that disrupt the extracellular matrix, interfering with normal tissue structure and function