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Touyz RM, Schiffrin EL

Oral administration of pregabalin (at a target dose of 150 mg/day in three divided doses, much less than gabapentin) significantly reduced the severity of sensory neuropathy induced by oxaliplatin by 1-2 grades

Immunity 36 , 10731086 (2012)

10.1056/NEJM199403033300907 58 LiuH.DengY.GaoJ.LiuY.LiW.ShiJ.et al

Icariin and icaritin exert anti-cancer effects through regulating gut microbiota Although its entire potential in cancer treatment has not yet been investigated, it has been discovered that icariin regulates the human intestinal microbiota

Subsequent deprotonation and dehydrohalogenation lead to the formation of 2-hydroxyindole and/or its tautomer, 3-substituted-2-oxindole [11,14]
