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This selectivity is important because it suggests the compound affects only its intended target rather than causing widespread metabolic disruption

[DOI] [PubMed] [Google Scholar] Higgins 2002 Higgins JP, Thompson SG

Research from Oxford University demonstrates that mepolizumab not only reduces eosinophil counts but reverses the primed hyperactive state these cells develop in severe asthma. This treatment is specifically designed for patients with severe eosinophilic asthma , defined as having blood eosinophil levels of 150 cells per microliter or higher despite using high-dose inhaled corticosteroids plus additional controllers

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