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This shift in iron homeostasis correlated with the repression of multiple virulence factors regulated by Fur and PrrF, including quorum-sensing components, efflux pumps, and phenazine biosynthesis enzymes

Fecal levels of Bacteroidetes are reported to be elevated in ME/CFS 57

doi: 10.1136/jmg.2008.061895

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(2) age-related decline and chronic stress-mediated impairment of protein quality control pathways

Additionally, individuals exposed to environmental toxins or those with high levels of oxidative stress due to lifestyle factors may also benefit from IV glutathione therapy