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The severity of the disease is strongly associated with advanced age and other existing comorbidities in patients, such as metabolic syndrome, resulting in mortality rates above 50% in individuals over 65 years of age

doi: 10.3390/antiox10030453 237 ZhangFLiXWeiY

It is also a key nutrient for building and repairing tissue, producing proteins and immune system health

The process works through several key steps: Folate converts to 5-methyltetrahydrofolate (5-methylTHF), which circulates in blood This form donates methyl groups necessary for DNA methylation After transferring methyl groups, SAM becomes S-adenosylhomocysteine (SAH) Much of American men over age 60 take dietary supplements containing folic acid [20]

[DOI] [PubMed] [Google Scholar] 65.Zuberbier T., Abdul Latiff A.H., Abuzakouk M., Aquilina S., Asero R., Baker D., Ballmer-Weber B., Bangert C., Ben-Shoshan M., Bernstein J.A., et al

Int J Cancer (1994) 58(4):4749.10.1002/ijc.2910580403 43 ZhengACastrenKSailyMSavolainenERKoistinenPVahakangasK