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Cigarette smoke, diesel exhaust, and grilled meats all contain PAHs.[ref] Aflatoxin B1 , a fungal component found on grains and peanuts, is detoxified by conjugation with glutathione using GST enzymes.[ref] Related article: Mold, Mycotoxins, and Your Genes Acrolein is an aldehyde used as a pesticide and a byproduct of tobacco smoke

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3) The causative organisms, through the cellular adhesion to the IECs of intestinal epithelial cells with the production of mycotoxic factors and genotoxins to promote carcinogenesis