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Prescription medicines such as semaglutide (injectable) and tirzepatide (injectable) produce larger average weight loss in high quality human trials than most supplements

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[Google Scholar] 47.EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies) Turck D., Bresson J.-L., Burlingame B., Dean T., Fairweather-Tait S., Heinonen M., Hirsch-Ernst K.I., Mangelsdorf I., McArdle H.J., et al

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2002 Feb 19;99(4):1870-5