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In contrast, food supplements are self-regulated by the manufacturer, and proof of effectiveness and safety are not required except where health benefits are being claimed

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doi: 10.3892/etm.2017.4441 89 JacobsenFMRudlangTMFodeMOstergrenPBSonksenJOhlDAet al

Mass spectrometry-based lipidomics: an overview

Direct provision of TMAO into diet has been shown to increase the development of atherosclerosis in animal models, confirming its pro-atherogenic properties 47 , and multiple clinical studies have confirmed that an elevated TMAO level is associated with increased risks for incident major adverse CV events 48