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See the sources that passed The regulatory position is unambiguous

doi: 10.1084/jem.168.6.2059 75 KieffERickinsonAB

PLoS One 9, e112050

Guo Z, Xie W, Lu J, Guo X, Xu J, Xu W, Chi Y, Takuya N, Wu H, Zhao L (2021) Tannic acid-based metal phenolic networks for bio-applications: a review

PLoS ONE 8 , e72533 (2013)

299 These results suggest that MAPK-related signaling pathways exacerbate ischemic brain injury, possibly by enhancing neuroinflammatory processes and BBB dysfunction
