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Step 1: Kisspeptin-10 activates KISS1R receptors in the hypothalamus Step 2: GnRH neurons release gonadotropin-releasing hormone in pulses Step 3: The pituitary gland responds by secreting LH and FSH Step 4: LH stimulates Leydig cells to produce testosterone Step 5: FSH supports spermatogenesis through Sertoli cells Natural kisspeptin levels in blood plasma decline significantly with age

The key mediator is hepcidin, which traps iron within macrophages and enterocytes, reducing its availability for red blood cell production

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Broad et al., 2020b

SCD1 catalyzes the desaturation of palmitic acid (16:0) into palmitoleic acid (16:1) and stearic acid (18:0) into oleic acid (18:1) 48

10 To counter this, generic firms may use skinny labeling, filing a Section viii statement to carve out patented uses from their label and launch their product only for expired indications