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Mechanisms of Vitamin B12 deficiency with Metformin Use: It has been proposed that metformin reduces Vitamin B12 absorption by following mechanisms Alterations in small bowel motility which stimulates bacterial overgrowth and consequential vitamin B12 deficiency Competitive inhibition or inactivation of vitamin B12 absorption Alterations in intrinsic factor (IF) levels and interaction with the cubulin endocytic receptor Inhibition of the calcium dependent absorption of the vitamin B12-IF complex at the terminal ileum Reference: Fatima, S., Noor, S

[DOI] [PubMed] [Google Scholar] 99.Kulkarni DH, et al

10.3390/ijms242417223 151 TongK

Research conducted on humans and animal studies indicate that IgG, whether alone or in immune complexes, is capable of activating mast cells and either initiate or exacerbate the severity of anaphylactic reactions

Chronic inflammation increases the risk of chronic long-term fertility issues, so early interventions, such as specific peptides that can modulate inflammation, like collagen peptides or SOCS-related compounds, can be used to rebalance and protect reproductive health