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To reduce NADPH production, cells were preincubated with glucose-6-phosphate dehydrogenase (G6PDH) siRNA (GenePharma, Shanghai, China) for 48 h or 100 nmol/L specific G6PDH inhibitor 6-aminonicotinamide (6-AN

This binding could modulate astrocytic glycogen storage and lactate production, thereby translating peripheral metabolic information into changes in local neural circuit activity and influencing feeding behavior

This allows for faster absorption and higher bioavailability compared to oral supplements, helping your body receive the nutrients it needs more efficiently

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Reduced CII activity has consequences for central carbon metabolism because CII is involved in the conversion of succinate to fumarate within the TCA cycle 73

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