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Wei, H., Zhang, W

It affects multiple organ systems including the respiratory, cardiac, hematological, neurological, renal and gastrointestinal structures
Additional factors in the assessment of severe depression include thoughts of suicidality and inpatient status.3,8,11 Severe depression is associated with a greater number of comorbidities, a longer time to treatment response, greater risk of recurrence, and greater likelihood of suicide.3,8 Chronic depression, defined as depression in which patients are symptomatic more days than not over a 2-year period, is associated with a high rate of treatment resistance.3,11 Patients with MDD are often affected by anxiety symptoms

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