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Dosing tiers: Oral administration (500 mcg to 1.5 mg/day) targets gut-specific inflammation: IBD, colitis, and intestinal barrier dysfunction

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Animal reproduction studies with semaglutide have shown embryofetal toxicity, including structural abnormalities, at exposures below those expected at therapeutic doses in humans

Treated mice showed decreased susceptibility to muscle damage, improved muscle strength, reduced PARP activity, increased NAD + levels, and elevated mitochondrial function 254 , thus suggesting a potential therapeutic benefit of NR supplementation in DMD