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Moreover, the size and molecular composition of PDEVs vary widely depending on their cellular origin, physiological state, and environmental conditions [46]

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elegans , we assessed hsp-4 induction in response to heat shock and tunicamycin treatment in an xbp-1 loss-of-function mutant background (Supplementary Fig

Within the H-site, the substrate analogue ( 12 ) interacts through hydrogen bonds to N108 and the backbone of V12, a interaction with F112, water bridges to R16 and Y175, and hydrophobic interactions with V12 and V115 (Fig