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Simon et al., 2020

The amino acid cysteine actively contributes to cancer metabolic remodelling on three different levels: first, in its free form, in redox control, as a component of the antioxidant glutathione or its involvement in protein s -cysteinylation, a reversible post-translational modification

Intracellular GSH depletion is regarded as an early step of apoptosis as it occurs before loss of mitochondrial integrity, cytochrome c release, and activation of caspases [8]

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To determine the significance of such overexpression, we evaluated the effect of silencing GSTO1 on cancer cell viability