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Penetration of stroma-rich 3D PDAC spheroids The desmoplastic ECM acts as a pathological barrier which impedes drug diffusion and penetration into PDAC tissue

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Multiple complementary pathways potentially synergistic

However, this finding may be limited to the specific mouse model, given the fundamental functions of P40 and CD25 in immune tolerance

Physiol Behav 66:785795 Willis GL, Robertson AD (2004) Recovery of experimental Parkinsons disease with the melatonin analogues ML-23 and S-20928 in a chronic, bilateral 6-OHDA model: a new mechanism involving antagonism of the melatonin receptor