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Stereoselective reduction by an imine reductase yields the amino acid (2S, 6S)-6-methyl-pipecolic acid ( 290 ) that is incorporated by the citrinadin NRPS into the natural product as the methylpiperidine moiety

the lactate-to pyruvate ratio, which mirrors the cytosolic NAD + /NADH redox equilibrium, provides a substantially greater discriminatory power [17]

Is it the disease process that affects the blood levels

If a peptide can be prepared in a stable, practical liquid solution after regulatory and formulation review, it makes sense to remove unnecessary complexity

To arrive at suitable cutoff values, the sensitivity associated with various cutoffs used in MetDP was explored (see Additional file 1: Figures S1 and S2)

If your skin feels raw or looks red, press pause