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Patients are educated on avoiding triggers such as shift work, alcohol, tobacco, prolonged bed rest, weight gain, lack of sleep, and stress, while promoting strategies to manage fatigue including increasing exercise, consuming nocturnal protein snacks, and employing ergogenic nutrition ( Pharmacological treatments, however, have shown limited evidence of effectiveness in alleviating fatigue

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[ ] Practice 5 minutes of diaphragmatic breathing twice daily (morning and evening)

Targeted silencing or complete global knockout of KDM3A expression significantly mitigated oxidative stress, suppressed NF-B/P65 activation, reduced apoptosis and fibrosis, and improved cardiac function, which indicates the therapeutic potential of HDMi in diabetic cardiovascular injury [227]

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