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These products would potentially enter the TCA cycle for further metabolism, which was confirmed by the up-regulation of related enzymes

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However, consistent with FGFR4-mediated suppression of CYP7A1, which catalyzes the rate limiting step of cholesterol metabolism to bile acid, aldafermin significantly increased LDL-cholesterol and non-HDL cholesterol without exerting a consistent effect on insulin, glucose, or HbA1c