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doi: 10.1586/17474124.2015.1092872

Headaches: Headaches can occur as a side effect, though they are generally mild and short-lived

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For most people the honest answer is: often at first, then much less often once your stores are refilled

Also consider a folate supplement (680 to 1,360 mcg DFE, or 400 to 800 mcg folic acid), particularly if you're a woman in your childbearing years