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Description
Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition

Nephrol Dial Transplant 23:991997 Mantovani G, Macci A, Madeddu C, Gramignano G, Serpe R, Massa E, Dess M, Tanca FM, Sanna E, Deiana L, Panzone F, Contu P, Floris C (2008) Randomized phase III clinical trial of five different arms of treatment for patients with cancer cachexia: interim results

Ischemic glutamate receptor hyperactivation stimulates phosphatidylinositol-specific PLC, cleaving PIP 2 into IP 3 and diacylglycerol (DAG)

PGC-1 is known to be induced in response to energy-demanding conditions such as cold exposure in BAT [15] and exercise in skeletal muscle [16]

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Obesity and lipid stress inhibit carnitine acetyltransferase activity
