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Summary: Cells of the osseous system express the GHR and the IGF-1R and secrete IGF-1 that acts in an autocrine/paracrine fashion
In addition, the effect sizes of the results for memory and vigor appeared to be quite high, indicating that the effects of lowering the GH dose are quite substantial and may be assumed to have clinical significance
doi: 10.1007/s00449-020-02353-1 480 ZhangC.YangM.EricssonA
K.SantosA
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Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness
