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Meena et al., 2017)

Cancer and other multifactorial illnesses, including atherosclerosis, hypertension, MetS, and diabetes, have received considerable attention during the last decade because of the potential relevance of epigenetic mechanisms in explaining the remaining unknown heredity factors

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It was created based on a newly cemented understanding of the genetic relationship between GPX4 and its clinical manifestations, but with effectively no detailed knowledge of the underlying disease pathogenesis

It also interacts with other Wnt signaling pathway components including Dishevelled and PP2A (protein phosphatase 2A)