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India's population-weighted PM2.5 level sat at 48.9 g/m in 2025, nearly ten times the WHO's annual guideline, and IQAir's 2025 World Air Quality Report found 66 of the world's 100 most polluted cities sit within India

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It was also reported in DRG neurons of wild type and TRPV4 knockout mice that activation of TRPV4 by paclitaxel induced mechanical allodynia and excessive ROS production, although the allodynia and oxidative stress was partially decreased by the TRPV4 antagonist treatment (Materazzi et al., 2012) (Table 1)

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