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doi: 10.1038/nature11551 46 LozuponeCAStombaughJIGordonJIJanssonJKKnightR

doi: 10.1111/ajd.13186 404 LiLHanZNiuXZhangGJiaYZhangSet al

Despite the prevalence of quercetin in foods, its bioavailability in humans is relatively low due to poor water solubility and extensive first-pass metabolism

As a core metabolic product, lactate may promote the release of inflammatory mediators (e.g., IL-6, TNF-) by activating the TGF- signaling pathway, while enhancing NF-B pathway activity to exacerbate local inflammatory infiltration in lung tissue but this direct activation has not been demonstrated in COPD airway cells

Huang et al., 1998, Huang et al, 2000b)

Blood was centrifuged in a standard centrifuge (Labofuge 300, Heraeus Holding, Germany) at 3000 g 10 min