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The dose-response curve between 8 and 12 mg shows diminishing returns, meaning 10 mg captures most of the benefit while potentially reducing some of the dose-related side effects seen at 12 mg

An in vivo study showed that BC rats, after pomegranate juice administration, showed reduced IL-6 , TNF- , and HIF-1 expression compared to BC animals

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Toll-like receptor agonists (R848) can activate toll-like receptors and promote the transformation of TAMs to the M1 phenotype, showing anti-tumor efficacy in mouse tumor models (245)