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This effect is achieved by amplifying SIRT1, triggering the activation of both Wnt/-catenin and sonic hedgehog pathways (38)

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doi: 10.1371/journal.pgen.0020183

Stable intake of BR extract can reduce hypercholesterolemia and hepatic inflammation induced by excessive choline in a high-cholesterol diet via decreasing the levels of cecal TMA and serum TMAO in rats ( Hawthorn genus, in which phenolic compounds such as (-)-epicatechin, hyperin, and isoquercitrin are considered effective ingredients (85)

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Three-dimensional image acquisition The samples were imaged with Zeiss LSM880 microscope, using a plan-Apochromat 63x/1.4 Oil DIC, and a 405-nm diode laser, 488 nm line of argon laser, 561-nm DPSS diode laser, 633-nm HeNe laser: with 70-nm xy pixel size, and 210-nm z -spacing