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These various neutrophil-derived oxidants have different reactivities and specificities for biological targets, with protein thiol groups being particularly susceptible

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In neurons, as well as in numerous types of tumor cells, mitochondrial malic enzymes allow for the utilization of the amino acid glutamine as a fuel source

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These mitochondrial stress signals are transmitted to the nucleus, where they initiate adaptive metabolic responses through transcriptional reprogramming or other cellular activity pathways [91]