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Past works have found that fisetin can inhibit senescence markers (p53, Bcl2, Cxcl1, and Mcp1)in DSS-induced UC in mice, upregulating the expression of micro RNAs (miRNAs) miR-149-5p, miR-96-5p, miR-34a-5p, and miR-30e-5p and the abundance of Akkermansia muciniphila , which is negatively correlated with senescence and inflammation [146]

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An even more challenging task will be to elucidate the functional impact of such changes, both in terms of their quantitative influence on the biological activity of the affected protein, as well as their fractional control over the integrated network of subcellular and cellular regulation

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