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For very young dogs, supplementation is rarely the first lever unless a veterinarian has a specific reason

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Repeated FIB-4 measurements can help identify individuals at risk of severe liver disease

In addition to these environmental factors, other population differences, such as linkage disequilibrium of the GPx-1 locus with other specific modifying genes, the influence of other gene variants that act to modulate GPx-1 activity [such as the SelP subtypes mentioned above (252)], and/or the presence of other gene variants that act in concert with GPx-1 to modify disease risk may also explain differences among studies performed in different populations