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The supernatant was collected after LPS administration, with or without IAP, adenosine, adenosine + uridine, guanosine, cytidine, and thymidine pretreatment

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Similarly, BHB has been shown to reverse the loss of dopaminergic neurons and glial activation and inhibit microglial pyroptosis by negatively regulating STAT3-mediated NLRP3, resulting in the downregulation of pro-inflammatory cytokines [85]

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Researchers observed the anti-inflammatory efficacy of these phytocompounds, employing ELISA and Western blot analysis on mouse macrophages via downregulation of pro-inflammatory cytokines [76]

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