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This is because ghrelin receptors are found in the pituitary gland, where they are called growth hormone secretagogue (GHS) receptors

Those with normal absorption can be maintained on oral replacement

Renal failure and/or hepatic failure : Follow phenobarbital levels and re-dose accordingly

People who cannot absorb B-12 will need regular injections since your body needs B-12 to function properly

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doi: 10.1038/nprot.2012.024
