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Both agencies emphasize the need for well-controlled studies, pharmacovigilance plans, and clear evidence of benefit over risk
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2004a Apr 1;19(7):739-47
Furthermore, silymarin inhibits the expression of iNOS, thereby reducing the production of nitric oxide (NO) and subsequently lowering inflammation
It modulates inflammatory cytokines and supports the gut-brain-immune axis, making it effective for both musculoskeletal injuries and gastrointestinal disorders
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