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iron-responsive proteins/iron-responsive elements (IRPs/IREs) hamper the transfer of iron by disrupting the stability of transferrin receptor mRNA while promoting the transcription and synthesis of ferritin to enhance the binding of free iron (6466)

The novel mechanism for the neuroprotective effect of saffron was found through the regulation of P2X7 receptors, which are affected in AMD [231, 232]

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Additionally, metabolites like shortchain fatty acids and indole derivatives increased, exhibiting proven immunomodulatory functions and promoting host metabolic regulation via colonic Gpr41/Gpr43 and AhR signaling pathways [73]

Biomaterials offer the potential for precise STING agonist delivery and can expand the therapeutic window by increasing drug potency and reducing side effects