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Finally, the scope and design of the FIH trial and subsequent studies (e.g., treatment duration) must be considered in order to design appropriate pivotal preclinical studies that will both enable the planned clinical studies and adequately inform of potential safety risks for the intended patient population or healthy volunteers

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Membrane associated CD14 forms a receptor complex with TLR4 (a pattern recognition receptor) and Myeloid differentiation 2 (MD2) and plays an important role in binding LPS, as well as initiating the immune response