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Inhibition of NNMT: 1-MNA has been shown to inhibit the enzyme NNMT, which when present in high levels, is associated with various diseases

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Clin Med (Lond) 2015;15:145150

The combination has been associated with elevated sirtuin activity, altered adipocyte differentiation markers, and changes in muscle stem cell quiescence and proliferation in the cited preclinical literature

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If you experience dryness or sensitivity, consider using GHK-Cu every other day or alternating days with your retinoid
