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The reason for this is that the initial wave of drug-induced hepatocellular destruction is followed by a robust innate immune response, in which invading inflammatory cells release toxic oxidants and cause a second wave of destruction

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A study in human melanoma has described that LECs support the recruitment of nave T cells in the local TME through secretion of CCL21, which is induced in response to VEGF-C (131)

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CARNITOR may alleviate the metabolic abnormalities of patients with inborn errors that result in accumulation of toxic organic acids
